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cialis (tadalafil)

Pharmaceutical medicine Cialis: peculiarities, mechanism of action and dose

cialis (tadalafil)

Main action of Cialis

Tadalafil is the active component of this medicine. The medicine action is directed to the slowing down the enzyme cGMP. Generation of nitric oxide is reached at the stimulation of penis, and this in its turn causes inhibition of the enzyme PDE5 and a sharp increase of cGMP content in the penis cells. These factors provide the main effect of the drug Cialis and namely the relaxation of the musculature of the corpus cavernosum, blood flow and the improvement of erection for prolonged sexual intercourse. Such effect cannot be reached without sexual stimulation of a men. Cialis is not aphrodisiac and does not affect the vitality of sexual desire.

The active component of Cialis does not inhibit other types of enzymes, and therefore does not have a significant impact on human. Its admission does not affect the functions of the heart and circulatory system, does not affect the level of filtering of liver, and does not affect the relaxation or spasm of transverse muscles. Clinical research allows speaking about a neutral impact on sperm quantity and life cycle of sperm. Cialis has no effect on hormones: this includes all types of hormones. The main effect of medication begins after 15 minutes of oral consumption. It may last more than 1.5 days.

The active ingredient of the medicine gets in the blood through the digestive system. Studies have shown that the concentration of active substance in blood plasma reaches its maximum in 120 minutes after Cialis intake. Food and water in the stomach does not influence the speed of action of the active ingredient and its duration. The active substance is bound in the organism and is excreted after 17 hours. Kidneys and digestive system participate in the excretion.

Which cases is this medicine prescribed in?

Aggravation of erection, problems with its quality and the duration of sexual intercourse.

Cialis 10 mg

Cialis 10 mg - a drug for treating erectile dysfunction. It has the safest formula, which is improved and effective. Restrictions on consumption are minimal and side effects are reduced. Also, a combination of drug intake with alcohol and fatty foods is permissible.

Cialis 20 mg

Cialis 20 mg - a modern drug to combat an inability to achieve and maintain an erection. It differs from other medications due to its long-lasting action, which under ideal conditions can possibly last up to 48 hours. Men are recommended to take Cialis 20 mg about 30-40 minutes before the planned sexual activity. It is recommended to begin drug usage with lower dosage of 10 mg. If the sexual life is irregular, then it is possible to use 20 mg. It must be remembered that this is the maximum dosage per day. If there are serious problems with the liver, kidneys and/or cardiovascular system, it is not recommended to exceed the dosage of 5 mg. It is necessary for the safety of health.

Cialis 40 mg

The medicine, Cialis 40 mg, is indicated for the treatment of potency in men. The improved composition of the drug, in which Tadalafil is the main active ingredient, allows you to effectively deal with the problems of male sexual impotence for 36 hours after ingestion. Drug Cialis 40 mg should be taken 30-40 minutes before the intended sexual intercourse. The substance will have the most effectiveness when using it this way. For the first time, a reduced dose of 20 mg should be taken in order to evaluate the body's response to the substance.

Cialis 60 mg

Cialis 60 mg is a unique drug that helps to increase masculine sexual strength. The advantage of this medication over analogues is that it has a higher effectiveness, regardless of how bad sexual problems are in patient. Another advantage is the duration of the effect achieved from its usage: it lasts up to 36 hours. No other medical product can show such properties.

Cialis Professional

Generic Cialis Professional 20 mg, thanks to a new pharmacological formula, relieves erectile dysfunction problems in men. The drug helps to increase erection, and sexual intercourse becomes longer and brighter. Due to increased blood flow to the pelvic organs, the penis increases in size and it gives a new strength to your intimate relationships.

Cialis Soft

Cialis Soft (in a dosage of 40 mg) refers to the latest generation of drugs aimed at solving problems associated with the work of the reproductive system in the male half of humanity. The drug appeared not so long ago on the market of medical products designed to improve potency in men.

Cialis Super Active

For years, men around the globe have been actively using the drug Cialis to solve problems associated with erectile dysfunction. You can find a lot of positive reviews about the results achieved after using this medicine. However, not all men were equally pleased with the duration of the achieved erection and the effect of the drug exclusively on the problems of the reproductive system that are associated with impotence. To solve all these problems, Cialis Super Active was developed.

Medicine intake

The medicine is produced in the form of firm-coated tablets. Tablets are taken orally with lots of plain water. There is no need in the chewing or dissolving of the tablet in a mouth. These actions do not influence the speed of the action of active ingredient. The patient should plan his sexual intercourse and take into account the time period of 20 minutes because the action of Tadalafil starts after this period of time after administration. Daily dose is 1 tablet.

Negative action of the medicine for an organism

The clinical research showed the perfect tolerance by all groups of persons. But some adverse effects were registered. They are as follows:

  • headache
  • diarrhea (short-term liquid stool)
  • pain in back and lumbar spine
  • hyperemia of upperparts
  • stuffiness in nose
  • weakness, sometimes myalgia of upper and lower extremities
  • pain in eyes
  • redness of the eyeball mucous membrane
  • profuse lacrimation
  • allergic reaction

Pay attention: in the clinical practice the cases of prolonged erection were registered. If the patient has the erection more than 4 hours he should seek medical assistance. The prolonged erection negatively affects the nutrition of the tissues of the penis and this may lead to serious consequences.

Contraindications

This drug is developed for men and therefore it is not prescribed to women. It is contraindicated the prescription of Cialis for children less than 18 years of age. If a patient has individual intolerance to the medicine or its components, he should immediately stop the administration. It is contraindicated to prescribe Cialis to patients who use in their treatment the agents from the group of nitrates.

Cardiovascular diseases are complex conditions and therefore doctors often prohibit patients with this diagnosis sexual contact. The patients who recently suffered myocardial infarction (particularly transmural, with considerable damage of cardiac walls) should not take Cialis. Also the patients with established heart failure of 2 degree and unstable angina should not administrate the medicine. The direct contraindication for Cialis administration is the presence in history of arrhythmia and arrhythmia. It is prescribed with caution at the increased or decreased blood pressure. The same applies to systemic blood diseases, benign and malignant tumors, leukemia and anemia. It is contraindicated to take the medicine to persons with congenital or acquired curvature of the penis, and sclerosing processes in the corpora cavernosa. Chronic renal failure is an indication for additional examination of the patient. And only then Cialis may be prescribed. It is forbidden to combine the treatment with antiarrhythmic and Cialis taking, especially with beta blockers.

Combination with other medicines

The combined intake of Cialis and nitrates leads to lower blood pressure. The combination of inhibitors of CYP3 A4 and Cialis increases its concentration in blood plasma. It is contraindicated the intake of Cialis and corticosteroids, erythromycin. Please note: antacids and medicines obducing mucous coat of stomach are used in the treatment of gastritis and gastric ulcer. They can reduce the absorption rate of the active ingredient of Cialis and its level of concentration in the blood. It is desirable to exclude the combination of antihypertensive drugs and Cialis.

Overdose

Exceeding the permissible dosage of the medicine increases the chance of negative effects. There is no direct antidote to Tadalafil. The symptomatic therapy is prescribed in the case of detection of side effects or in case of excess dosage.

Storage conditions

The medicine should be kept in a dry place. Keep out reach of children. The storage temperature is 15 – 25C.